许多研究表明，DNA甲基化和组蛋白修饰参与了发育过程中的基因抑制(Cedar, and Bergman, 2009)。组蛋白甲基化参与异染色质的形成，是可逆的。另一方面，DNA甲基化被发现具有稳定的长期抑制作用(Ng, and Adrian, 1999)。很明显，DNA甲基化和组蛋白修饰途径是相互依赖的。这是由domanin组蛋白甲基转移酶和DNA甲基转移酶介导的。这种理解是必要的体细胞重编程和肿瘤发生的情况。在DNA甲基化的情况下，组蛋白修饰和染色质结构都是相互关联的。在正常健康细胞中，表观遗传控制机制使肿瘤相关基因沉默。然而，从最近的研究中发现，在睾丸癌的病例中，这些表观遗传调控因子的情况存在着深刻的差异。这导致了DNA甲基化和组蛋白修饰过程的异常行为。因此，需要对机制有一个全面和准确的理解来确定过程。这可以为将来控制睾丸癌细胞的肿瘤进展铺平道路。接下来有关加拿大商业论文代写-组蛋白修饰和DNA甲基化之间的联系分析如下：
Epigenetic control plays an important role in the production of germ cell development any deviation could to abnormal proliferation of the germ cells. It causes issues in the apoptosis process (Van Der Zwan et al., 2013). There is an imperative need to understand the exact mechanism of the process in order to devise a proper strategy to understand the actual mechanism (Grewal, and Moazed, 2003). This would lead to developing interventions for the tumour, fertility problems to name a few (Van Der Zwan et al., 2013).
DNA methylation and histone modification are one of the most significant forms of epigenetic modification (Cedar, and Bergman, 2009). Histone modification is considered to be a covalent post-translational modification to the histone proteins. It could be methylation, phosphorylation, acetylation, ubiquitylaton and sumoylation (Hunter, 2007). This research focuses on the methylation process. Histone methylation is the process by which methyl groups shifts and attaches itself to the amino acid of histone proteins of the chromosomes. It depends on the target site (Cedar, and Bergman, 2009). Methylation has the ability to transform histone to chromatin essentially to activity or deactivate the process. To elucidate further, it has been found that the histone trimethylation of the fourth lysine of histone H3 (H3K4me3) (Shi et al., 2006) and H3K9ac (Nishidaet al., 2006), leads to up regulation of the transcriptional activity. Transcriptional repression is again activated by the histones H3K27me3 (Berger, 2007), H3K9me2 (Riceet al., 2003) and H3K9me3 (Lachneret al., 2001).
5hmc and the members of the TET gene family are also involved in the DNA methylation process (Williams, Christensen, and Helin, 2012).
In the case of mouse fetal germ cell, many researches were undertaken to understand about the epigenetic programming of the DNA methylation and the histone modification process. Research indicates that DNA methylation process in germ cells has also been found to be integral for the meiotic progression in mice. Similarly human fetal germ cells also undergo changes. There is a lack of research in human fetal germ cells.
In this particular research there have been efforts taken to understand the epigenetic reprogramming in human germ cells. There are five histone marks that have been identified H3K9me2, H3K9me3, H3K27me3, H3K4me3, and H3K9ac. For this process an accurate time of DNA demthylation and DNA remethylation has been studies in this analysis. The relationship between DNA demethylation and human germ cell meiosis has been investigated in-vitro and Ex-vivo.