In another study conducted by McDonald et al. (2008) tried to identify the specific role being played by those fruits and vegetables which are alkali rich and their subsequent effect on only women population who have attained menopause and if these fruits or vegetables could improve bone health for them. They undertook their study specifically on post menopausal women belonging to 60-65 years of age group and were total 276 in number. These women were broadly divided into four groups and were randomly assigned to the same. One group was administered high dose of potassium citrate externally, the second group was assigned a comparatively much lower dose of the same, the third group was a placebo and the fourth group was fed large amount of fruits and vegetables which were highly rich in alkali. They were given regular doses at intervals for two years. The fasting serum and urine was collected at regular intervals of 3, 6, 12, 18 and 24 months respectively and the bone markers were studied from the obtained urine and serum samples. Another additional sample was randomly drawn between 4-6 weeks respectively.
The bone marrow density was measured initially at the baseline and after completion of two years. The data when compared did not show any significant in the long duration cases though the BMD of spine was less in the samples collected at 4-6 weeks in placebo compared to high dose potassium citrate case. When the results were compared for the long term administration, though there were little differences between lose dose potassium citrate administration or placebo with high dose potassium citrate administration, but these differences could not be considered significant.
Mc Donald et al., (2008) opined that though alkali rich food stuff or potassium citrate increased the bone calcium in the initial phases, but did not show significant difference upon long term administration suggesting that the provision for alkali in post menopausal women is unable to relate or depict a clear cut benefit of fruits and vegetables rich in alkali or administration of potassium citrate in the long term over the bones of females.