Breast cancer that starts out as a local disease is found to metastasize to the lymph nodes and distant organs. At a primary level diagnosis, the prognostic markets are to analyze the impact of these systemic diseases. In this, metastatic capacity is an important market to understand the impact of the tumor. Some research has pointed towards the direction that Breast cancer metastasis is acquired late through the tumor genesis events. Some have stated that this is a systemic disease. Nevertheless, any form of development of tumor in the breast cancer needs to be analyzed. Newer molecular technologies such as DNA microarray have helped in developing a prognosis for the disease and aids in understanding of the metastasis process .
Apart from these proven technologies to determine the Cancer progression, a number of researches have been undertaken to understand about the newer developments of Cancer. A number of newer treatments and methods of diagnosis have been derived to understand about breast cancer mechanism in adults. It has been found that studying the impact of HER (Human Epidermal growth Factor type 2) is an effective way of diagnosis of the disease . It has been found that in the case of breast cancer, the most important defense mechanism is early diagnosis.
For the purpose of identifying the cancer, selectins play an important role in detectin. Sections are a family of cell adhesion molecules (CAM). All the selectins that are found in the system are single chain transmembrans that are primarily glycoproteins. They are similar to the C-type selecting . Selectins primarily are found to bind to the sugar moieties. They are actually cell adhesion proteins that primarily bind to the sugar polymers. There are three types of selecting that have been identified.
There are three types of selectins. E selectin is found in the endothelial cells; L-selectins are found in the lymphocytes; P-selectins are found in the platelets and endothelial cell. Of these adhesion molecules, selectins in general are found to influence how they bind to the cells and play an important role in the dynamics of cell-adhesion. It has been observed that the selections are found to play an important role in the cancer cell metastasis of cells. These E-selectins are explained in detail in the following. The mechanism in which the E-selectin and E-Selectin ligands play an important role in breast cancer metastatic cascade has been elucidated in detail in the following.