由于所有的记忆痕迹都分布在大脑皮层，单一的损伤很难破坏或破坏所有的记忆痕迹。另一方面，内侧颞叶将储存大部分皮质记忆的位置，这些记忆的痕迹将会散布在小区域，并对大量的皮质记忆痕迹形成阻塞。内侧颞叶损伤是一种全球性、广泛性的损伤。如果健忘症是由内侧颞叶引起的，那么这种损伤是由于知识和事件的保留造成的(Bright et al.， 2006)。对内侧颞叶的损伤导致了顺行性遗忘的产生以及对最近发生的事件的逆行性遗忘。此损坏将为最近内存的存储保留内存。这些相互分离的皮层痕迹只有在海马状体中实际存储的指标的帮助下才能被完全获取。
As all the memory traces are distributed over the cortex, it gets difficult for the single lesion to break or destroy all the memory traces. On the other hand, the medial temporal lobe will store the location of the most cortical memory which will have the traces spread over the small regions, and it will have a block to the vast cortical traces of memory. The loss due to medial temporal lobe is generally global and vast in nature. In case of amnesia which is caused due to the medial temporal lobe the impairment is caused to the retaining of knowledge and events (Bright et al., 2006).The damages done to the medial temporal lobe cause damage the production of anterograde amnesia along with the retrograde amnesia for the events which took place recently. This damage spares the memory for the storages of the recent memory. The cortical traces which get disconnected with one another can only be accessed altogether with the help of the indices that are actually stored in the hippocampus.
Once all the memories start to retrieve the cortical then gets directly associated with one another and shall be accessed independently by the hippocampus. This process shall be known as the consolidation of the systems. Example of this can be given by the post. It notes that it is put in the books to find some of the particular pages and places. Once it is done, it really becomes easy to find that particular chapter or the important points. The medial temporal lobe of the memory system will consist of the hippocampus and is surrounded by the rhinal cortex. At the anterior part, the amygdala is located which will modulate the declarative memory in the region. The medial temporal lobe makes a considerable contribution to the recollection and the familiarity. The functioning of the medial temporal lobe is actually independent of the consciousness awareness that binds the distinct element of the event to the representations of the relationship. The role of the medial temporal role is very much important in the relational memory that are independent of the awareness.