论文代写价格-N-和o -链糖基化抑制剂的作用

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论文代写价格-N-和o -链糖基化抑制剂的作用。经验研究表明，糖基化抑制剂在很大程度上改变了N-和o -糖基模式，导致细胞的修饰，从而导致癌症的障碍。已经进行了许多分析技术和研究，以找出确定的糖基化抑制剂。研究发现，这些糖基化抑制剂在体内可有效地诊断和预后癌症。已经确定，治疗策略也可以从制定一个机制糖基化抑制剂。其中一项关于细胞凋亡调控的研究就是这样进行的。实验研究表明，UDP-GalNAc:多肽n-乙酰半乳糖氨基转移酶(ppGaNTases)是启动粘蛋白型o型糖基化的关键。即细胞的转移功能受到抑制。粘蛋白型o型糖基化在调节凋亡的ppGaNTases中是稳定的。这些抑制剂的作用是有效的表观遗传因素，导致控制癌细胞的扩散。

N-linked carbohydrates structures are fundamentally N Linked carbohydrate that i.e. liked through N-Acetylglucosamine and amino acid asparagine [45]. In the case of O-linked carbohydrate, it has been found that they have covalent attachments to the proteins that provide a linkage between the structure of monosaccharide N- Acetylgalactosamine and through the amino acids serine or threonine. The structural differences pave the way for different biochemical processes between the two structures. Aberrant glycosylation during the break cancer process has the ability to cause even the difficult blood brain barriers that have been found to exist in the system. Glycosylation during cancer formation even leads to the formation of tumor in the brain. The primary facilitators for this are the glycosyl transferase that has been found to exist in the system [47]. These cause changes in the carbohydrate chain and further cause metastasis function in the body. This altered gene expression needs to be controlled in order to essentially stop the aberrant glycosylation process. For this function, the use of glycosylation has been found to be effective. Glycosylation inhibitors affect the glycosylation function of the membrane protein that will affect adhesion between breast cancer cells and endothelial cells [11]. In other words, this has been found to be effective in essentially impeding the metastasis function of the cells. Empirical research has shown that the glycosylation inhibitors alter the N- and O-glycan patterns in a substantial amount causing modification of the cells that positively lead to the impediment of carcinoma. There have been a number of analytical techniques and researches that have been undertaken to find out about the definitive glycosylation inhibitors.
Deoxymannojirimycin (DMJ) has been found to be effective inhibitor for prevention of the cell adhesion between oligosaccharide layer of the viral and cellular oligosaccharide. This has led to more researches for the same[12]. It has been found that they can inhibit N-linked glycosylation by inhibiting mannosidase, which is a glycosylation process enzyme[9]. When using DMJ on glycoproteins, glycoproteins’ oligosaccharides are significantly altered, but DMJ doesn’t change the surface expression of them. Benzyl-N-acetyl-α-galactosaminide (Bzl-GalNAc) inhibits elongation of O-glycans by inhibiting glycosyltransferase incorporation of glucosamine into O-glycans [10].
Another technique that has been developed in recent times is the RAGE. It stands for Receptor for Advanced Glycation End products [41]. It is found to be an oncogenic transmembrane receptor that is found to be aberrantly expressed in the human cancer. The exact heuristics of this mechanism is still very unclear. It has been found that the RAGE expression is correlated with the degree of breast cancer progression in the cell. Owing to this, there is reduced expression of MCF-7, SK-Br-3 and MDA-MB-231 in the siRNA [42]. Owing to this, the aberrant expression can be prevented and this has been identified as a novel target for the breast cancer.
Hence, glycosylation inhibitors can serve as an important function in preventing aberrant glycosylation. Owing to this, a number of newer studies have been undertaken to ensure that this is controlled in the body. It has been found that DMJ, RAGe, Mucin-type O-linked glycosylation are some of the research that has been undertaken to solve the issue of aberrance glycosylation in the body.

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加拿大代写-研究策略的分类分析

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加拿大代写-研究策略的分类分析。研究策略分为调查研究、档案研究、案例研究、行动研究等不同类型。研究策略的重要属性是帮助研究者回答研究问题。这意味着，在满足研究目标和回答研究问题时，与研究相关的多种策略的替代方案适用于单一的研究研究。同样，这种研究方法要求研究者确保研究策略适用于符合研究目的。否则就会对研究的有效性和可靠性提出质疑。

The research strategy forms the third layer of the research onion. The research strategy consists of different types, such as, survey, archival, case study, action, etc. The attribute that is important with respect to the research strategy is helping the researchers to answer the research question. This means, the alternatives as to the multiple strategies related to the research is applicable to a single research study in meeting the research aim and answering the research question. Likewise, this method of the research requires the researcher in ensuring the research strategy that is applicable suiting the research aim. Otherwise the questions can be raised regarding the validity and reliability of the research.
This research study requires the researcher planning the conducting of the research with respect to the application of the survey and interviews. The reason that is primary is fact that the aims of the research are exploring the sustainability, inclusive business models, following international norms and standards, and voluntarily holding themselves accountable with respect to the financial and nonfinancial performance. By applying the survey, the exploration with respect to the views of the entrepreneurs regarding these aspects helps deduce the results.
Choices

The research choices are the fourth layer of the research onion. The research onion model reveals that the researcher has the choice of qualitative methods, quantitative methods, and/or both in a single research study. In this study, a mixed method is used with the use of survey and strategies of interview research. The findings of the survey will be helping to quantify the data, while the findings of the interview will be helping to express the data in a qualitative manner (Kumar, 2014).
Data Collection

The process of data collection can be pursued with the use of two methods. Saunders &Tosey (2013) suggests that research study data can be collected by either primary sources and/or secondary sources. There is more aestheticism and reliability with regards to the primary source of data collection as it is a product of the researcher. The secondary data, however, can be used with the help of the data and information expressed and collected by the others. The techniques used in the primary data collection include observation, focus groups, interviews and the surveys. The sources of the secondary data, on the other hand, include news articles, journal articles, books, industry reports, publications, archives, and financial statements.
In this research study, there will be application of two primary data collection methods of surveys and interviews. The interview will be conducted with entrepreneurs and entrepreneurs turned business leaders.

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代写价格-Hofestede文化模型解析

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代写价格-Hofestede文化模型解析。现代中国企业在经营中需要在不同的情景下招聘个人。如果公司计划扩大业务，它需要聘请多元文化资源(Hofstede, 2013)。他们应该了解公司的基本目标。如果公司计划将业务扩展到其他国家，它需要考虑Hofestede文化模式，并雇佣合适的人员。在为员工提供培训、评估和建立奖励制度时，也应提供类似的模式。Hofestede文化模式并不是领导者应该考虑的唯一因素。然而，这是全球领导者在员工管理方面应该考虑的最重要的方面之一。

In order to understand some of the contemporary issues that leaders face in the new era. It is important to understand the culture. Opening of markets to free trade and making people work in diversified environments has created an issue of managing people. Prior to opening of market the management structure was able to sustain in homogenous work environment. However in the new era this homogenous work management will no longer be beneficial. There is a need to understand the people coming in from different cultures. People management has essentially become more challenging. For managing of people from different culture there is no one single right approach. Hence a number of culture models have been implemented in order to understand the fundamental dynamics of the different societies across the spectrum (Hofstede, 2011). The management of people from different cultures within the organizational framework is imperative in order to cater to the global consumers. Hofestede model is one attempt in order to understand about the different societies, which factors in six major factors. Power distance index is used to measure the hierarchal control of traditional organizations. Individualism is professed in some cultures while other cultures follow collectivistic principles. Indulgence factors, long-term orientation, uncertainty avoidance index and masculinity factors are considered in this model (Hofstede, 2013).
Using this model as a formula the companies should develop specific aspects that are in line with the objectives of the company.
Beijing ECCO trading company is considered to be one of the best distributes of the famous Danish brand ECCO. Hence there is a need to understand the different culture rationale in order to maximize productivity. In this particular scenario being a Chinese distributor the company needs to understand the different types of cultures in societies that are not homogenous anymore. There is a need for an eclectic workforce in order to increase efficiencies and take into account the different perspectives. This can be reflected in the following practices. The company is currently a market leader and if it wants to expand its operations to other geographical zones and to maintain cordial relationship with the international investors it needs to focus on the following aspects.
Recruiting: Modern Chinese enterprises are operating in needs to hire personal in different scenarios. If the company is planning to expand operations it needs to hire multi cultural resources (Hofstede, 2013). They should understand the fundamental objectives of the company. If the company is planning to expand operations to other countries it needs to factor in Hofestede culture model and hire right personnel.

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代写论文-伊拉克的宗派主义之间竞争的影响

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代写论文-伊拉克的宗派主义之间竞争的影响。伊拉克的宗派主义已占了上风，各分裂集团之间的关系之间的力量始终是动态的。ISIL最终带来的挑战不具备通过军事手段解决的能力。虽然极端主义团体有能力疏远那些首先欢迎他们的社区，但政府将需要利用这种不满情绪，通过提供对民众的支持，而不是仅仅容忍(即使“伊斯兰国”在财政和战术上受到挤压)。任何低于这一点的事情，都可能导致另一场叛乱的发生。同样，新政府仍然需要说服库尔德人，当伊拉克统一而不是独立时，他们会取得更好的成功。与此同时，必须承认，这些任务只有在什叶派的强烈忠诚和国家偿付能力的参与下才能完成。

The rivalry between the majority of Shia and the minority of Sunni in Iraq has remained at the core of political conflict within the region. Tensions of sectarian nature have caused hindrance to the processes of building state and country’s destabilization. But the government in Iraq has not made an apparent effort for overcoming the divisions and building a general identity in the nation. As a matter of fact, most of the actions taken till now have served only as a means for furthering the struggling state fragmentation.
The divide of Sunni-Shia, historically was caused due to debates and disagreements over politics, theologies and doctrine issues. The modern expression of this divide however is driven due to power, resource and status based competition. Increasingly, political relations have been dominated through communal representation idea in opposition to representation of citizens. This has been exacerbated instead of easing out the present divide. The sectarian identities institutionalization has further led towards conflicts on size, borders, status and power of Sunni or Shia community. Such conflicts have led towards a destabilizing impact particularly when the conflicts have led to legitimizing the violent group’s actions claiming to depict individual communities. The essential dependence of Iraq on oil as its key revenue source has exacerbated further conflicts due to no clear equation present for resource management.
Conflicts of sectarian nature are followed by a kind of polarization with systemic nature due to rising authority of Nouri al-Maliki as Iraq’ Prime Minister. He has managed consolidation of his authority and he has engaged in parliament marginalization as well as individual institutes, military control, apparatuses of security, judiciary subjugation and political patronage expansion at the cost of his competitors. This has caused the Shia detractors to be alarmed but has not caused them to break their ranks of sectarianism.
Without a doubt, it can be said that Iraq is divided. Sectarian relations have now become a tool used through entrepreneurs in the political domain. These entrepreneurs use sectarianism to formulate mobilization of communities that influence the attitude of political elites that are looking at creation of constituents and famous support. This is specifically right during the season of elections when confrontational discourse is adopted by leaders for winning the supporters.
On theoretical basis, sectarianism does not have inevitability in societies that are plural and there does not exist any end to suggestions given by researchers on voting systems that lead towards blunting sectarianism. On practical level, such systems hardly work successfully. Once, identities with sectarian nature start mobilizing when transformation is taking place. It often happens that they become non-reversible either in the mid-term or short-term. Attempts made for blunting conflict through mandatory representatives for all groups, can help in maintaining peace to a certain limit but this helps in creating vicious trap through reinforcement of identities.In combination, this may cause conflict as in the case of Lebanon’s.

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加拿大商业论文代写-传统的理论分析

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加拿大商业论文代写-传统的理论分析。传统的理论在现实中行不通。在这些传统理论中，有许多无形的东西被忽视了。然而，一些关键的指标，如工资的重要性是在这个过程中确定的。这些方面是基本的，但不是员工应该重视的唯一因素。现代理论认为，员工的绩效随着真实的情感联系而提高。应该更加重视员工的情绪，提高生产力，促进增长。公司可以通过多种方式获得员工的忠诚度和凝聚力。获得员工忠诚和情感的主要原因是真诚地关心员工。综上所述，公司需要考虑像情感和工资这样的无形资产来激励员工。这一分析得出的结论是，基于行为的动机主要来自于情感的无形方面。

Traditional theories about management discusses about importance of money and salary. They base employee productivity to increase based in higher pay and remuneration. These theories are disregarded and considered to be obsolete because of there generalization that all employee work only for money. There is no discussion of personalization with the employees. The employees are considered to be automated machines (Riordan, Gatewood, & Bill, 1997). Taylor scientific management theory discusses the impersonal nature of work done by employees. Human behavior theorists and anthropologist have critiqued this notion. There are a number of factors that are considered in fostering productivity. These are based on emotions. This was proposed in Theory of X and Y and Elton Mayo theory. These theories stress the importance of emotions of the employees for performance. Modern day success companies have been probed to understand which facet is important to enhance productivity. From the case study analysis of various companies it has been found that money is an important factor. Nevertheless is not the only factor there are a number of other factors that has been associated for increasing in productivity. Mundane jobs like work in steel factory productivity were increased owing to the factors of aiding in employee autonomy (Kelliher, Hailey & Farndale, 2013). It was also found that the employees are generally more attuned to the needs of the organization when their individual needs were met. In the case of SAS Company it was found that the company offered incentives that was based on individual personal objectives it was found from this that the remuneration should be in tangent with the policy of individual objectives. From case study analysis of each of the company it was found that they tried to care genuinely for the employee needs and the need to meet personal objectives. This has lead to the employees to care for the organization.
Recommendations that can be proposed for the other organizations based on these aspects are as follows.
Paying employee wages according to the industry standards.
Apart from salary, companies should offer employees a number of fringe benefits
Listening to needs of the employees and trying to change organizational system based on these needs (Kelliher, Hailey & Farndale, 2013).
There is a need to understand employee objectives
Recognizing and rewarding the employee on significant achievement
Finding ways to boost morale of the employees. This can be done conducting regular surveys, feedbacks from employees (Kelliher, Hailey & Farndale, 2013).
Developing effective teams that are formed from real emotional connection.
There should be some level of collectivistic practices and also individual remuneration.
Culture of the organization should be determined from employee needs and objectives. (Kelliher, Hailey & Farndale, 2013).
Expecting to change the policy and adapt to the newer events of the society
Determining best practice approaches that are suitable for each company’s objective.
Flexibility and capacity to adapt according to the reasonable demands of the employees would result in all round organizational progress (Kelliher, Hailey & Farndale, 2013).

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